The session will explore the latest breakthroughs in cell-based therapies, including CAR-T and TCR therapies, and their growing role in cancer treatment. With a focus on the significant progress made in targeting difficult cancers, the session will also address the ongoing challenges in improving patient outcomes and managing safety concerns like cytokine release syndrome (CRS) and relapse. At Cell & Gene Therapy World Conference 2025, experts will explore the potential of combining cell therapies with other treatments to enhance efficacy. Additionally, the session will consider the ethical implications, such as equitable access to these therapies and long-term patient safety.